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Table 1 Summary of studies included in the comparisons between MMRM and LOCF_ANCOVA

From: The efficacy of duloxetine: A comprehensive summary of results from MMRM and LOCF_ANCOVA in eight clinical trials

Study

Treatment Duration

Drug

Number of Patients

Drug Dose & Design

1

9 weeks

Placebo

122

-

  

Duloxetine

123

60 mg/d (QD)

2

9 weeks

Placebo

139

-

  

Duloxetine

128

60 mg/d (QD)

3

8 weeks

Placebo

70

-

  

Duloxetine

70

40–120 mg/d (20 mg-60 mg BID)

  

Fluoxetine

33

20 mg/d (QD)

4

8 weeks

Placebo

75

-

  

Duloxetine

82

40–120 mg/d (20 mg-60 mg BID)

  

Fluoxetine

37

20 mg/d (QD)

5

8 weeks

Placebo

90

-

  

Duloxetine

91

40 mg/d (20 mg BID)

  

Duloxetine

84

80 mg/d (40 mg BID)

  

Paroxetine

89

20 mg/d (QD)

6

8 weeks

Placebo

89

-

  

Duloxetine

86

40 mg/d (20 mg BID)

  

Duloxetine

91

80 mg/d (40 mg BID)

  

Paroxetine

87

20 mg/d (QD)

7

8 weeks

Placebo

93

-

  

Duloxetine

95

80 mg/d (40 mg BID)

  

Duloxetine

93

120 mg/d (60 mg BID)

  

Paroxetine

86

20 mg/d (QD)

8

8 weeks

Placebo

99

-

  

Duloxetine

93

80 mg/d (40 mg BID)

  

Duloxetine

103

120 mg/d (60 mg BID)

  

Paroxetine

97

20 mg/d (QD)