Fig. 1

Study design. After study enrolment, patients were scheduled for standardized strength assessment at three time points (t1-t3) to measure the maximal muscle strength. The parkour consisted of consisting of four commercial fitness devices addressing leg extensors and flexors (a), arm extensors and flexors (b), back extensors (c), and abdominal flexors (d). At t1-t3, disease severity, daily medication, body weight, and selected blood parameters were assessed. Abbreviations BPRS Brief Psychiatric Rating Scale, MADRS Montgomery–Åsberg Depression Rating Scale, t time point YMRS Young Mania Rating Scale. The scheme of the fitness devices was provided by courtesy of milon industries GmbH, icons were obtained from Biorender